Application of iPSCs in Disease Modeling
The rapid development of cell reprogramming allows scientists to freely obtain the cell types of a specific tissue, bypassing the dependence of human tissue and primary tissue. By infecting the disease to be studied and controlling the development process of the disease in the culture dish, we can explore the pathogenesis and development process of the disease. In conclusion, iPSCs reprogramming provides a certain pathological model for the study of several diseases and deepens the understanding of these diseases.
In addition, effective treatment results can be obtained by applying new drug treatments on disease models based on iPSCs technology. For example, cardiomyocytes formed by iPSC differentiation induced from a patient's somatic cells possess the genetic characteristics of the patient and the ability to respond to the patient's disease phenotypes. The use of such cell-cultured disease models to screen and identify new drugs can be effective in treating or preventing disease. Using this cell culture disease model to screen and identify new drugs can effectively treat or prevent disease while avoiding the reliance of researchers on human-derived cardiac tissue and primary cardiomyocytes.
Fig.1 Steps of disease modeling. (Cherry, 2013)
Design of the Disease Model
Many factors need to be considered in the design and testing of disease models. Because of the tremendous variability in the behavior of pluripotent cell lines, researchers at Creative Bioarray use genetically identical, disease-corrected controls to create valid disease models. Genetic correction for the disease genotype in the affected iPS line of the patient is the best control for any disease model. With our advanced cell reprogramming technology platform, we help our clients establish robust protocols for differentiating iPSCs into target tissues and determining a cellular phenotype that is both specific to cells carrying the disease genotype and disease related.
Our Solutions
Cell reprogramming technology has been widely used in disease modeling. We provide customers with professional technical support and flexible solutions to help customers establish effective disease models through cell reprogramming.
- iPSC-based Cancer Modeling
- iPSC-based Mitochondrial Disease Modeling
- iPSC-based Retinal Disease Modeling
- iPSC-based Neurodegenerative Disease Modeling
- iPSC-based Kidney Disease Modeling
- iPSC-based Heart Disease Modeling
- iPSC-based Liver Disease Modeling
- iPSC-based Respiratory Disease Modeling
- iPSC-based Eye Disease Modeling
- iPSC-based Infectious Disease Modeling
- iPSC-based Diabetes Modeling
- iPSC-based Rare Disease Modeling
- iPSC-based Chimaeric Disease Modelling
Utilizing a Disease Model
- Application as research tools for mechanistic research
- Application as the basis of drug screens
Advantages
- Professional research platform
- Continuous innovation of technology
- Time-saving and competitive price
Creative Bioarray has helped customers create models of dozens of genetic diseases using iPS cell technology, and the insights generated from these models will help researchers gain new inspiration for therapeutic drugs. If you need our technical support, please feel free to contact us.
Reference
- Cherry, A.B.C.; Daley, G.Q. Reprogrammed cells for disease modeling and regenerative medicine. Annual review of medicine. 2013, 64: 277-290.