The development of multicellular organisms is a very delicate and complex coordinated process, and cell populations of the same species have their own unique homeostasis, so that the transformation between different types of differentiated cells does not occur spontaneously under natural conditions. But the process of cell differentiation can be reversed by experimental techniques to change the state from one set of gene expression profiles to another, so as to realize the transformation of cell type, that is, reprogramming.
In order to reprogram somatic cells or somatic nuclei to a wide range of developmentally plastic states, Creative Bioarray has developed advanced cell reprogramming platforms to help customers obtain the desired cell types by using a variety of technologies such as nuclear transplantation, cell fusion, chemical induction, and induction of specific transcription factors.
Nuclear Transplantation Mediated Cell Reprogramming
For mammals, we generally obtain reconstructed embryos by somatic cell nuclear transfer, and restore the totipotency of donor cells under the action of oocyte reprogramming.
Cell Fusion Mediated Cell Reprogramming
Fusion of differentiated somatic cells with pluripotent stem cells can be used for cell reprogramming, but the efficiency of obtaining hybrid cells is extremely low. The new cell fusion system we have developed significantly improves the efficiency of reprogramming.
Transcription Factor Mediated Cell Reprogramming
Cell Reprogramming platform offers a variety of concise and efficient strategies for achieving transcription factor-mediated reprogramming, which provides new insights into cellular plasticity and advances the field of biomedicine.
Chemically Induced Cell Reprogramming
The small-molecule-mediated reprogramming technology we have developed is easily controlled in a concentration and time-dependent manner. It provides a high level of cell permeability and is suitable for mass-producing cells.
