OECs have attracted increasing attention from researchers as potential therapeutic agents for neuro repair. Creative Bioarray is committed to helping clients develop strategies to convert patient-accessible non-neural cells such as OECs directly into induced neurons for CNS repair. We look forward to working with you and being your indispensable scientific assistant in the field of cell reprogramming.
OECs-to-Neurons Reprogramming
Olfactory ensheathing cells (OECs) are a distinct type of glial cell derived from the olfactory plate and play key roles in the spontaneous growth of olfactory axons in the olfactory nervous system. OECs are present in the peripheral nervous system and CNS, have the ability to promote axonal regeneration, and are now widely used in experiments to treat CNS injury by transplantation. Studies have shown that OECs and astrocytes have the same molecular, morphological and functional characteristics. Based on their superior compatibility with host astrocytes and relative clinical accessibility, OECs are considered ideal target cells for reprogramming to obtain induced neurons.
In recent years, scientists have made efforts and progress in reprogramming OECs into functional neurons to provide source cells for transplantation after CNS injury. The use of OECs as the starting cells for reprogramming has been reported to have a high conversion rate and have an added benefit of displaying neuroprotective properties in non-reprogrammed OECs. Therefore, rapid access to neuronal cells from adult OECs is a valuable area of exploration with broad potential for neurological disease modeling and cell-based therapies.
Fig.1 Induction of neuronal fate on OECs. (Sun, 2019)
Our Services
To help clients obtain induced cells that have typical neuronal morphologies, express multiple neuron-specific markers and form functional synapses, Creative Bioarray provides clients with services to reprogram OECs into induced neurons. Our services include but are not limited to:
- Helping clients screen for transcription factors that can effectively reprogram OECs into neuronal cells to develop straightforward and rapid reprogramming strategies.
- Optimizing experimental conditions to effectively promote the maturation of induced neurons such as the addition of neurotrophic factors or co-culture with astrocytes.
- Providing genome-wide RNA sequencing analysis and bioinformatics analysis to further confirm the effectiveness of reprogramming OEC transcriptomic profiles into neuronal lineages.
Applications
- Study on personalized disease modeling
- Development of cell replacement-mediated therapeutic approaches
- Research in the field of neurology
Advantages
- Years of experience in cell reprogramming services
- Efficient technical support
- Flexible solutions adapted to customers' scientific needs
- Strict quality control system
With our innovative research team and advanced reprogramming technology platform, Creative Bioarray is capable of providing professional neural reprogramming services and delivering high-quality reprogrammed cells and scientific experimental reports to our clients. If you need our services, please feel free to contact us for consultation.
Reference
- Sun, X.; et al. Direct neuronal reprogramming of olfactory ensheathing cells for CNS repair. Cell death & disease. 2019, 10(9): 1-17.