To develop the potential of iPSC technology in studying the mechanisms of human neurodegenerative diseases, Creative Bioarray focuses on building in vitro models of the most common age-related neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), to help our clients explore new therapies.
iPSC for Modeling Neurodegenerative Diseases
Neurodegenerative diseases are associated with abnormal neurological function and are age-related, characterized by the degeneration and eventual loss of neuronal function. These debilitating and intractable diseases result in a wide range of clinical symptoms, involving decreased cognitive and/or motor function, which has a serious impact on individuals and society. Despite promising preclinical data, the inability of traditional animal models and cell culture to accurately replicate human pathophysiology has hindered the possibility of capturing a complete view of human disease and clinical trials of neuroprotective drugs.
There is an increasing urgency to establish a human disease modeling platform for neurodegenerative disease research. Researchers are currently developing complex iPSC-based differentiation systems to comprehensively encapsulate human tissue-level and organ-level dysfunction and apply them to disease modeling studies. The phenotypes of cells differentiated from iPSCs provide good models for early-onset diseases because of their fetal-like properties. Importantly, these models carry the same genetic variants correlated with pathogenesis in specific microenvironments, helping researchers to identify the pathological mechanisms that are involved in neurodegenerative diseases.
Fig.1 Schematic of reprogramming-based approaches for the generation of human neuron models of disease. (Qiang, 2013)
Our Solutions
Human brain-like organs have proven to be a powerful tool for modeling the pathophysiology of various neurodegenerative diseases. Our researchers have developed iPSC-based neurodegenerative disease models focusing on the two most common diseases. In addition, to reconstruct authentic interactions between cells, we have also developed more complex 3D culture models, including hydrogels, spheres, extracellular matrix (ECM)-derived scaffolds, and organoid cultures.
Applications
- Neurodegenerative disease mechanism and progression analysis
- Study on host-pathogen interactions
- Prediction of onset and progression
- Research on cell replacement therapies
Advantages
- Highly trained technical staff
- Advanced iPSC technology platform
- Expert cell culture technology
- Short experimental period and direct data availability for article publication
Creative Bioarray has a specialized and advanced technology platform for iPSC reprogramming-based disease modeling to help researchers understand the etiology and pathogenesis of a wide range of neurodegenerative diseases and develop new therapeutic approaches. We provide cost-effective technical support and rational solutions to our clients. If you need our services, please contact us directly.
Reference
- Qiang, L.; et al. Remodeling neurodegeneration: somatic cell reprogramming-based models of adult neurological disorders. Neuron. 2013, 78(6): 957-969.