Skin tissue engineering is a challenging clinical problem. Creative Bioarray is committed to exploiting the great potential of cell reprogramming in the field of regenerative medicine and using iPSCs to generate skin cells and model skin diseases to develop clinical therapies for skin regeneration in chronic wounds and skin diseases. We look forward to providing you with complete and reliable solutions for your research projects.
Background
Non-healing ulcers are becoming increasingly common and place a significant burden on healthcare systems worldwide. Wounds that do not heal for long periods often cause bacterial infections that increase the severity of the wound. Available treatment options include wound debridement, growth factors, antibiotics, and stem cell transplantation therapies. However, the clinical application of these strategies is limited by their limited success and high cost. Advances in regenerative medicine offer additional therapeutic options to potentially improve wound healing and restore normal skin structure.
The emergence of cell reprogramming techniques has greatly impacted the field of regenerative therapies. iPSC can provide unrestricted access to a variety of skin cells to generate complex, personalized 3D skin structures for autologous transplantation and disease modeling. Currently, researchers have made significant progress in differentiating iPSC into skin cells such as folliculogenic human epithelial stem cells, keratin-forming cells and fibroblasts to engineer skin substitutes.
Fig.1 Various types of skin cells are generated from iPSCs. (Choudhury, 2021)
Solutions for Skin Tissue Engineering based on Cell Reprogramming
To help our clients develop skin tissue engineering based on cell reprogramming for accelerated healing and ideal skin regeneration, we provide our clients with the following solutions:
- iPSCs differentiation into all three germ layers is used to accelerate each stage of wound healing. For example, preclinical models of acute and chronic wounds, including burn wounds, diabetic wounds, and herpetic epidermolysis bullosa, have been treated with iPSC-derived keratinocytes and endothelial cells.
- Integration of iPSC-derived skin cells, including fibroblasts and epithelial stem cells, into the construction of artificial skin replacements that can effectively heal skin injuries to ensure long-term survival and functional improvement of skin structures. For example, we have successfully combined human iPSC-derived melanocytes with keratinocytes and fibroblasts to construct human skin equivalents with functional epidermal melanin units.
Advantages
- Good hardware facilities
- Efficient service model
- Team of experts from research institutes and laboratories
- Scientific and rational solutions
As a technology-focused cell reprogramming service company, Creative Bioarray has accumulated rich and professional experience in the field of skin tissue engineering based on cell reprogramming. We have the strength to provide professional technical support to accelerate the progress of your research. If you need further information, please contact us.
Reference
- Choudhury, S.; et al. Recent advances in the induced pluripotent stem cell-based skin regeneration. Wound Repair and Regeneration. 2021.