Equipped with a class-leading cell reprogramming technology platform and an outstanding research team, Creative Bioarray has established several efficient novel neural reprogramming methods, including the use of iPSCs or direct reprogramming, to efficiently obtain specific neuronal cell types for therapeutic applications. We look forward to being your scientific assistant and providing professional scientific services to accelerate the progress of your projects.
Neuronal Reprogramming
The need for sources of specialized cell types for cell replacement therapies and disease modeling studies has triggered the rapid development of novel cell reprogramming methods. In recent years, many strategies have been established in the field of neuroscience to obtain reproducible sources of different neuronal cell types, including strategies of efficiently differentiating pluripotent stem cells and strategies of direct reprogramming involving the conversion of fully differentiated somatic cells into induced neurons.
Both in vitro and in vivo cell reprogramming provide multiple therapeutic avenues for modeling neurological diseases and injury repair. In particular, new opportunities have opened up for regenerative medicine in the central nervous system and retina. The feasibility of in vitro derivation using iPSC reprogramming or direct reprogramming to generate specific neurons, provides an important scientific basis for researchers to develop regenerative strategies for repairing the nervous system in disease and injury settings.
Fig.1 Timeline of milestones in neuronal reprogramming for brain repair. (Liou, 2020)
Strategies for Neuronal Reprogramming
We offer neuronal reprogramming strategies including but not limited to:
- Use of iPSCs as a cell source for neuronal production.
- Neuronal differentiation of iPSCs using growth factors and small molecules.
- Neuronal differentiation of iPSCs using transcription factors.
- Direct reprogramming to generate neurons.
- Generation of neuronal by direct reprogramming using transcription factors.
- Generation of neuronal by direct reprogramming strategies using microRNA and small molecules.
Services
The generation of specific neuronal subtypes is critical for improving modeling and advancing cellular therapies for neurodegenerative diseases. Creative Bioarray has established various neuronal reprogramming strategies to help clients generate a variety of specific neuronal subtypes such as dopaminergic neurons, cholinergic neurons, excitatory cortical neurons, glutamatergic neurons, etc.
Applications
- Modeling neurological diseases and injury repair
- Development of therapies for retinal degenerative diseases
- Investigation of pathogenetic mechanisms
- Application for testing therapeutic interventions such as neuroprotective compounds
Advantages
- Creative and professional research team
- Efficient technical support
- Custom services
- Competitive price
With extensive experience in the field of neuronal reprogramming, Creative Bioarray offers clients the services to efficiently differentiate into various neuronal subtypes using growth factors, transcription factors, or small molecules. If you are interested in our neural reprogramming services, please contact us for more details.
Reference
- Liou, R.H.C.; et al. Neuronal reprogramming for tissue repair and neuroregeneration. International journal of molecular sciences. 2020, 21(12): 4273.