Vascular Tissue Engineering based on Cell Reprogramming

As an industry leader in the field of cell reprogramming, Creative Bioarray is committed to helping clients apply cell reprogramming techniques to develop autologous tissue-engineered vascular constructs to develop new approaches to treat vascular disease. Our best-in-class technology platform and specialized solutions will accelerate our clients' projects.


The vascular system acts as a dense network of blood vessels that transport blood within an organism to deliver nutrients and oxygen. The development of vascular diseases may lead to vascular obstruction and tissue ischemia. Vascular replacement to restore blood flow at the level of greater circulation is an effective therapeutic strategy for these disorders. To create vascular replacements, scientists have explored techniques in the fields of stem cell biology, cell engineering and materials science. In addition to smooth muscle cells, endothelial cells and fibroblasts, reprogrammed cells and pluripotent stem cells have also been used for vascular tissue engineering.

The eventual goal of vascular tissue engineering is to develop small-diameter cell-based vascular grafts with natural arterial biological and mechanical properties to resist thrombosis and support graft patency. Recent studies have demonstrated the possibility of generating powerful and durable engineered vessels from human iPSC-derived endothelial cells. The rapid development of vascular tissue engineering based on cell reprogramming helps researchers deeply understand the mechanism of vascular regeneration and develop new strategies for innovative therapies.

Fig 1. Personalized vascular tissue.Fig.1 Personalized vascular tissue. (Chen, 2021)

Solutions for Vascular Tissue Engineering based on Cell Reprogramming

Vascular Tissue Engineering based on Cell Reprogramming

For many years, researchers at Creative Bioarray have worked to develop cell reprogramming-based vascular tissue engineering. To generate powerful and durable engineered blood vessels, we provide our clients with solutions that include, but are not limited to:

  • We have established robust selection markers and improved experimental protocols to reproducibly direct human iPSC into vascular lineages for vascular regeneration.
  • We cultured human iPSCs-derived endothelial cells in 3D microfluidic devices to form stable and reusable micro-vessels.
  • We have developed an efficient method involving bioreactors to engineer elastic functional vascular smooth muscle tissue for regenerative medicine and tissue engineering applications.


We offer a variety of rational and flexible solutions for our customers and help them apply the technology in the following ways:

  • Accelerate basic vascular biology and molecular pharmacology research by establishing iPSC-based vascular disease models.
  • Advance autologous treatment of diabetic vascular complications, particularly diabetic wound healing, by generating patient-specific iPSC-derived vascular cells.
  • Improve regeneration of functional pulmonary vascular system by repopulating vascular compartments of decellularized human lung scaffolds with human iPSC-derived smooth muscle cells and endothelial cells.

Equipped with a state-of-the-art technology platform, Creative Bioarray is committed to developing cell reprogramming-based vascular tissue engineering and providing specialized solutions to our clients. Please contact us if you are interested in our services. We will be glad to discuss the details of the projects with you.


  1. Chen, S.G.; et al. Vascular tissue engineering: advanced techniques and gene editing in stem cells for graft generation. Tissue Engineering Part B Reviews. 2021, 14-28.
For Research Use Only. Not For Clinical Use.