Biophysical and Biochemical Regulation for Cell Reprogramming

iPSCs reprogramming and direct reprogramming have been widely studied and are considered promising approaches for disease modeling, drug screening and personalized medicine. However, the efficiency of reprogramming remains to be optimized. It is well known that the microenvironment affects the behavior and fate of cells. Therefore, scientists are gradually focusing on the impact of biomaterials on iPSCs reprogramming and direct cell conversion. Currently, there are increasing reports on the integration of biomaterials into cell reprogramming to modify the microenvironment to improve reprogramming efficiency and achieve effective in situ cell reprogramming.

Biomaterials can be classified into biophysical and biochemical properties based on their characteristics. The former mainly consists of biomaterial morphology, stiffness, ligand pattern, ligand density, three-dimensional (3D) environment, thermal properties, and size and mechanical properties of micro/nanoparticles, while the latter consists of extracellular matrix composition or immobilized ligands. Biomaterials and devices have been applied to manipulate the external biochemical and biophysical cues for efficient cell reprogramming. Notably, developments in polymerization chemistries and micro- or nano-fabrication technologies have accelerated the design and manufacture of biomaterials with desirable physical and chemical properties.

Various biophysical and biochemical cues for cell reprogramming.Fig.1 Various biophysical and biochemical cues for cell reprogramming. (Fang, 2020)

Development Services

To meet the scientific needs of our customers, researchers at Creative Bioarray focus on the impact of microenvironmental factors on cellular reprogramming, including micro/nanomorphology, stiffness, external cellular stimulation, 3D microenvironments and biochemical modifications to develop strategies to improve reprogramming efficiency.

Why Choose Us

We focus on the development of biomaterials and their use as powerful artificial microenvironments to study and guide the fate of stem cells in culture and in vivo. We combined biomaterials technologies and cell biology to provide new insights into cell reprogramming approaches. To date, we have successfully developed multiple biophysical and biochemical factors-mediated approaches to improve reprogramming efficiency.

Our Industry Advantages

  • We have the leading technology and creative research team to provide reliable scientific services to our clients.
  • We will strictly keep the client's entrustment confidential.
  • Our efficient and rapid solutions will help our clients to save scientific research funds reasonably.

As a supply platform for cell reprogramming services, Creative Bioarray helps customers develop strategies to improve the efficiency of cell reprogramming through biophysical and biochemical regulation. We focus on the synergy of cell biology and biomaterials technologies to advance our clients' research in the field of cell reprogramming. Please contact us directly for technical support if you have a need.


  1. Fang, J.; et al. Engineering biomaterials with micro/nanotechnologies for cell reprogramming. ACS nano. 2020, 14(2): 1296-1318.
For Research Use Only. Not For Clinical Use.