iPSC opens up a whole new avenue of possibilities for researchers to understand disease mechanisms and explore potential therapeutic approaches for a cure. Creative Bioarray is dedicated to developing strategies for generating patient-specific iPSC-derived retinal cells for retinal disease modeling to help scientists accelerate basic and translational research.
iPSC for Modeling Retinal Diseases
Inherited retinal diseases such as retinitis pigmentosa are the leading causes of irreversible and incurable vision loss. Clinical treatments for these conditions are currently very limited. Although various rodent model systems have provided some of the key information on the pathogenesis of retinal diseases, species-specific differences and lack of disease-related tissue availability have proven to be a serious limitation in some cases.
Recently, considerable attention has been paid to the use of patient-specific iPSC-derived retinal cell types. Differentiation of iPSC into diverse disease-relevant cell types can be used to bridge the gap between molecular or cellular mechanisms and clinical phenotypes, enabling drug screening and the development of new therapeutic agents. Recent advances in this technology hold the promise of not only identifying mutated genes, but also halting the progression of vision loss in early cases. In conclusion, as a platform for researching patient-specific targeted disease cells, iPSCs have exciting potential for human disease modeling and regenerative medicine.
Fig.1 Retinal pigmented epithelium (RPE) differentiation from hiPSC. (Rathod, 2019)
Our Solutions
With our extensive experience in the field of cell reprogramming, Creative Bioarray provides professional solutions and technical support for the use of patient-specific iPSCs in the construction of 3D disease models and models of various retinal diseases. We help our customers develop and utilize iPSC based retinal disease models in the following aspects:
- Identification of disease-causing mutations in patients through next-generation sequencing.
- Helping clients uncover the cellular and molecular mechanisms that lead to retinal diseases.
- Using disease models for small molecule drug screening to develop drugs that can stop the progression of vision loss.
- Providing strategies to develop new therapeutic approaches by combining allogeneic or autologous cell replacement therapy with gene correction.
Applications
- Application in cell replacement therapy and clinical trials
- High-throughput drug screening assays
- Toxicity testing
Advantages
- Reliable and efficient solutions
- Entire experiments conducted by a team of experts
- Professional service with fast turnaround time
- Experienced in drug development projects
Creative Bioarray has developed a variety of advanced cellular reprogramming strategies to provide our clients with comprehensive scientific services in this area. We help our clients establish in vitro platforms suitable for modeling retinal degenerative diseases by generating retinal cell types from iPSC. If you would like to inquire further about our services, please contact us.
Reference
- Rathod, R.; et al. Induced pluripotent stem cells (iPSC)-derived retinal cells in disease modeling and regenerative medicine. Journal of chemical neuroanatomy. 2019, 95: 81-88.