Human iPSC-based systems have been shown to overcome the limitations of species-specific of inflammatory responses and infectious pathogenicity. Creative Bioarray has been focused on the development of iPSC-based models of infectious diseases, providing valuable and useful tools for clients to explore host-pathogen interactions.
iPSC for Modeling Infectious Disease
The rapid development of cell reprogramming technology holds great promise not only in cell therapy and regenerative medicine, but also in the simulation of different disease conditions, including infections disease. Human pathogens severely affect the health of patients through complex interactions with the host. Researchers often select primary cells or immortalized and transformed cells to study the role of host genetic variants in infection. However, in vitro models used to study the impact of host genetics on viral pathogenesis are very limited due to tissue scarcity and challenges in primary cultures. The development of cell reprogramming techniques has made it possible to generate host- and tissue-specific cells from iPSCs for infectious disease studies.
Fig.1 Personalized model of HCV infection obtained by infecting iHLCs from one donor with HCV from another donor. (Schwartz, 2012)
Our Solutions
To help our customers simulate host-pathogen interactions using iPSC, we offer the following solutions:
- Modeling infections at the cellular level using iPSCs.
- Modeling viral infections in 3D systems. For example, validating the inhibitory effect of hit compounds on the ability of Zika virus to infect neural tissue by human iPSC-derived forebrain organoids.
- Modeling bacterial infections, for example, using human iPSC-derived intestinal-like organs to simulate Salmonella infection.
Applications
Current applications of iPSC technology in our company for the study of human viral infections include the following:
- In vitro modeling of viral infections in hepatic, neural, and cardiac cells.
- Genome editing and genetic engineering of patient-specific iPSC-derived cells to confer antiviral resistance.
- Modeling human genetic susceptibility to severe viral infectious diseases such as severe influenza and encephalitis.
Service Features
- Leading expert in the field of stem cell biology, regenerative medicine and therapeutics.
- Covers infections by a variety of pathogens such as coronavirus, influenza virus, coxsackievirus, herpes simplex virus 1, T. cruzi, T. gondii, N. meningitidis, S. agalactiae, Salmonella, and more.
- High-quality services, reasonable solutions and cost-effectiveness.
Creative Bioarray is dedicated to developing human iPSC-derived systems to model host-pathogen interactions in various infectious pathogens and organ systems. Our professional technical support and efficient solutions will bring you satisfactory scientific services. If you are interested in our cell reprogramming technology platform, please contact us directly for more information.
Reference
- Schwartz, R.E.; et al. Modeling hepatitis C virus infection using human induced pluripotent stem cells. Proceedings of the National Academy of Sciences. 2012, 109(7): 2544-2548.