In these recent years, tissue engineering is rapidly developing as an emerging discipline that applies knowledge and techniques from the fields of biology and engineering to develop biological substitutes for repairing and promoting the function and morphology of various tissues or organs in the human body after injury. Compared to traditional autologous or allogeneic tissue and organ transplantation, this technique overcomes the shortcomings such as insufficient donor sources. Currently, the application of cell reprogramming techniques to develop new tissue engineering approaches to treat diseases involving the lack of proliferating cells for tissue repair is a promising approach.
In certain diseases of tissue injury such as myocardial infarctions and cartilage injuries, terminally differentiated somatic cells lose their ability to proliferate and therefore the damaged tissues cannot heal by themselves. Tissue engineering based on cell reprogramming offers the possibility of healing such diseases. Recently, many cell phenotypes have been generated via transdifferentiation, such as neuronal cells and skeletal muscle cells, to promote regeneration of damaged tissues in vivo. Several studies have indicated that this technology has been successfully applied to treat liver disease in mice models as well as several brain-related diseases, and has also been used to generate tissue-engineered vascular grafts for the treatment of damaged blood vessels.
Fig.1 Potential of iPSC for regenerative medicine, disease modeling, and drug discovery. (Romanazzo, 2019)
Solutions for Tissue Engineering based on Cell Reprogramming
Given that grafts obtained from cell reprogramming showed great promise for future applications in tissue engineering, researchers at Creative Bioarray are focusing on basic tissue engineering research, especially the repair of important organs such as myocardial repair and bone tissue repair. We provide our customers with the following solutions:
- Muscle Tissue Engineering based on Cell Reprogramming
- Vascular Tissue Engineering based on Cell Reprogramming
- Skin Tissue Engineering based on Cell Reprogramming
We are committed to the development of iPSCs-based skeletal muscle tissue engineering to help clients develop optimal therapeutic approaches to restore or repair injured or degenerated tissues.
We are dedicated to helping our clients apply cellular reprogramming techniques to develop autologous tissue-engineered vascular constructs to develop new approaches to treat vascular disease.
We focus on developing clinical treatments for skin regeneration in chronic wounds and skin diseases using cellular reprogramming techniques.
Advantages
- First-class laboratory equipment
- Professional and efficient
- Reliable
- Safety
We have professionally educated technicians to perform the experiments.
We have a dedicated research team to provide reasonable solutions to our clients' projects.
Standardization of experimental operations and procedures to ensure the scientific validity of the results.
All experiments are conducted under confidentiality agreements with a focus on client privacy.
Based on a team of dedicated scientists, Creative Bioarray is dedicated to developing efficient cell reprogramming technologies and applying them in the field of regenerative medicine. We are committed to providing rational and efficient solutions to meet our clients' research needs in cell reprogramming-based tissue engineering. Please feel free to contact us for more details.
Reference
- Romanazzo, S.; et al. iPSC bioprinting: where are we at? Materials. 2019, 12(15): 2453.